Repatha *

Description

Repatha (generic name: evolocumab) is a prescription medication classified as a PCSK9 inhibitor, a type of monoclonal antibody. It is designed to lower low-density lipoprotein cholesterol (LDL-C) levels in the blood. By inhibiting the PCSK9 protein, Repatha increases the number of LDL receptors on liver cells, enhancing the clearance of LDL-C from the bloodstream.

Evolocumab is approved for use in adults with heterozygous familial hypercholesterolemia (HeFH) or homozygous familial hypercholesterolemia (HoFH), both genetic conditions characterized by high cholesterol levels. It is also indicated for patients with established cardiovascular disease to reduce the risk of heart attack, stroke, and coronary revascularization. Additionally, Repatha is used as an adjunct to diet and maximally tolerated statin therapy in patients who require additional LDL-C lowering.

DosageThe doctor will determine the dosage and treatment. Do not exceed the prescribed dose. Read the Product Information leaflet for full instructions on how to administer the dose.

Storage Repatha should be stored in its original container under refrigeration at 36-46°F (2-8°C). If necessary, it may be kept out of the refrigerator at room temperature below 77°F/25°C for up to 30 days, but once removed from refrigeration, it should not be returned and must be used within 30 days or discarded.

Do not use if any part of the pre-filled syringe or pen appears cracked or broken, if the grey needle cap on the pre-filled syringe is missing or not securely attached or if the medicine is discolored or contains large lumps, flakes or colored particles. If you are in any doubt, consult a doctor or pharmacist bfore using Repatha.

Questions about RepathaHow is Repatha administered?Repatha is administered as a subcutaneous injection using a prefilled syringe, autoinjector, or on-body infusor. The injection is typically given in the thigh, abdomen, or upper arm. Patients or caregivers can be trained to administer the injections at home.

Can Repatha be used alone?Repatha is usually used in combination with a healthy diet and maximally tolerated statin therapy. It is not typically used as a standalone treatment but may be considered in patients who cannot tolerate statins.

How does Repatha help in cardiovascular disease?By lowering LDL-C levels, Repatha reduces the risk of cardiovascular events such as heart attacks and strokes in patients with established cardiovascular disease.